Interval Mapping of Quantitative Trait Loci for Time-to-Event Data with the Proportional Hazards Mixture Cure Model
نویسندگان
چکیده
منابع مشابه
Interval mapping of quantitative trait loci for time-to-event data with the proportional hazards mixture cure model.
Interval mapping using normal mixture models has been an important tool for analyzing quantitative traits in experimental organisms. When the primary phenotype is time-to-event, it is natural to use survival models such as Cox's proportional hazards model instead of normal mixtures to model the phenotype distribution. An extra challenge for modeling time-to-event data is that the underlying pop...
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When censored time-to-event data are used to map quantitative trait loci (QTL), the existence of nonsusceptible subjects entails extra challenges. If the heterogeneous susceptibility is ignored or inappropriately handled, we may either fail to detect the responsible genetic factors or find spuriously significant locations. In this article, an interval mapping method based on parametric mixture ...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2006
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2006.00585.x